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KMID : 0624620130460100490
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BMB Reports
2013 Volume.46 No. 10 p.490 ~ p.494
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BAG5 regulates PTEN stability in MCF-7 cell line
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Zhang Ying
Gao Haiyan
Gao Haidong
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Abstract
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The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor-suppressing lipid phosphatase that is frequently absent in breast tumors. Thus, the stability of PTEN is essential for tumor prevention and therapy. The ubiquitin-proteasome pathway has an important role in regulating the functions of PTEN. Specifically, carboxyl terminus Hsp70-interacting protein (CHIP), the E3 ubiquitin ligase of PTEN, can regulate PTEN levels. In this study, we report that BCL-2-associated athanogene 5 (BAG5), a known inhibitor of CHIP activity, reduces the degradation of PTEN and maintains its levels via an ubiquitylation-dependent pathway. BAG5 is identified as an antagonist of cell tumorigenicity.
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KEYWORD
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BAG5, CHIP, PTEN, Ubiquitin, Ubiquitination
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